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The design of engineered materials and structures is a growing and increasingly impactful field of research that intersects materials science, engineering design, engineering mechanics, manufacturing, and data science. The overarching goal is to accelerate the discovery of new materials for engineering applications. The approach compliments a traditionally empirical, trial-and-error approach to discovery with an inverse, requirements-driven approach that strategically leverages material databases, simulations and engineering design algorithms and methods to synthesize new materials and structures. Papers are sought that integrate materials modeling, data collection, simulation, and prediction capabilities with engineering design methods, principles, algorithms, and tools to enable the design of new materials and structures. To be appropriate for this special issue in the Journal of Mechanical Design (JMD), papers must demonstrate an intellectual emphasis on engineering design.